Assessing Antimicrobial Activity of Platelets Rich Plasma

Abstract

In India, the prevalence of bacterial skin infections remains alarmingly high, particularly in rural and underserved populations. Wound infections, including diabetic wounds, surgical, burn wounds, chronic and other non-healing wounds, posing a major burden on healthcare resources and patient quality of life. Current topical drugs used in the treatment of skin wounds, such as silver sulfadiazine, chlorhexidine, and antiseptics, exhibit diminished efficacy, mainly due to the development of microbial resistance, overdose, and repetitive use. Considering these challenges, there has been a growing interest in biological therapies that promote tissue regeneration while offering antimicrobial benefits. Platelet-rich plasma (PRP), a concentrated autologous preparation of platelets in plasma, is one such versatile therapy that has demonstrated efficacy in enhancing wound healing. As a rich reservoir of growth factors and immune mediators, PRP has been extensively explored for its regenerative and antimicrobial properties, making it a promising candidate in wound healing and infection control. Apart from their healing capacity, PRP exerts antimicrobial effects, modulatesinflammation, and improves local oxygenation, making it a powerful therapeutic agent in both acute and chronic wound management. In the present work, PRP antimicrobial effects were tested by varying platelet counts to evaluate their dose dependent potential.